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Searching for Drug Synergy in Complex Dose–Response Landscapes Using an Interaction Potency Model

Rational design of multi-targeted drug combinations is a promising strategy to tackle the drug resistance problem for many complex disorders. A drug combination is usually classified as synergistic or antagonistic, depending on the deviation of the observed combination response from the expected eff...

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Huvudupphovsmän: Bhagwan Yadav, Krister Wennerberg, Tero Aittokallio, Jing Tang
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier 2015-01-01
Serie:Computational and Structural Biotechnology Journal
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Länkar:http://www.sciencedirect.com/science/article/pii/S2001037015000422
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