Single-Cell Transcriptome Analysis Reveals Inter-Tumor Heterogeneity in Bilateral Papillary Thyroid Carcinoma

BackgroundThe tumor microenvironment (TME) plays a pivotal role in cancer progression in papillary thyroid carcinoma (PTC), yet the composition and the phenotype of cells within the TME in bilateral PTC are poorly understood.MethodsWe performed unbiased transcriptome-wide single-cell RNA sequencing...

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Detalhes bibliográficos
Main Authors: Tiantian Wang, Jinyuan Shi, Luchuan Li, Xiaoming Zhou, Hui Zhang, Xiaofang Zhang, Yong Wang, Lian Liu, Lei Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-04-01
Colecção:Frontiers in Immunology
Assuntos:
scRNA-seq
papillary thyroid carcinoma
tumor microenvironment
immune dysfunction
bilaterality
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2022.840811/full
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