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An Improved Method for Modeling Voltage-Gated Ion Channels at Atomic Accuracy Applied to Human Cav Channels

Summary: Voltage-gated ion channels (VGICs) are associated with hundreds of human diseases. To date, 3D structural models of human VGICs have not been reported. We developed a 3D structural integrity metric to rank the accuracy of all VGIC structures deposited in the PDB. The metric revealed inaccur...

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Autori principali: Wilnelly Martinez-Ortiz, Timothy J. Cardozo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2018-05-01
Serie:Cell Reports
Accesso online:http://www.sciencedirect.com/science/article/pii/S2211124718305539
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