The HTLV-1 oncoprotein Tax is modified by the ubiquitin related modifier 1 (Urm1)

Abstract Background Adult T-cell leukemia/lymphoma (ATL) is an aggressive malignancy secondary to chronic human T-cell lymphotropic virus 1 infection, triggered by the virally encoded oncoprotein Tax. The transforming activity and subcellular localization of Tax is strongly influenced by posttransla...

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Main Authors: Rita Hleihel, Behzad Khoshnood, Ingrid Dacklin, Hayssam Omran, Carine Mouawad, Zeina Dassouki, Marwan El-Sabban, Margret Shirinian, Caroline Grabbe, Ali Bazarbachi
Format: Artigo
Language:Inglês
Published: BMC 2018-04-01
Series:Retrovirology
Subjects:
ATL
HTLV-1
Tax
Urm1
NF-κB
Oncogenesis
Online Access:http://link.springer.com/article/10.1186/s12977-018-0415-4
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