Effect of Vesicle Size on the Cytolysis of Cell-Penetrating Peptides (CPPs)

A specific series of peptides, called a cell-penetrating peptide (CPP), is known to be free to directly permeate through cell membranes into the cytosol (cytolysis); hence, this CPP would be a potent carrier for a drug delivery system (DDS). Previously, we proposed the mechanism of cytolysis as a te...

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Bibliographic Details
Main Authors: Kazutami Sakamoto, Takeshi Kitano, Haruka Kuwahara, Megumi Tedani, Kenichi Aburai, Shiroh Futaki, Masahiko Abe, Hideki Sakai, Hiroyasu Ohtaka, Yuji Yamashita
Format: Artigo
Language:Inglês
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
cell-penetrating peptide (CPP)
direct permeation (cytolysis)
giant unilamellar vesicle (GUV)
FITC–octa-arginine (FITC–R8)
vesicle size
gel phase
Online Access:https://www.mdpi.com/1422-0067/21/19/7405
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