Inhaled gold nanoparticles cause cerebral edema and upregulate endothelial aquaporin 1 expression, involving caveolin 1 dependent repression of extracellular regulated protein kinase activity

Abstract Background Gold nanoparticles (Au-NPs) have extensive applications in electronics and biomedicine, resulting in increased exposure and prompting safety concerns for human health. After absorption, nanoparticles enter circulation and effect endothelial cells. We previously showed that exposu...

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Main Authors: Ching-Yi Chen, Po-Lin Liao, Chi-Hao Tsai, Yen-Ju Chan, Yu-Wen Cheng, Ling-Ling Hwang, Kuan-Hung Lin, Ting-Ling Yen, Ching-Hao Li
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-10-01
Colecção:Particle and Fibre Toxicology
Assuntos:
Gold nanoparticle
Aquaporin 1
Endothelial cell
Caveolin 1
ERK
Edema
Acesso em linha:http://link.springer.com/article/10.1186/s12989-019-0324-2
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