CASSETTE—clindamycin adjunctive therapy for severe Staphylococcus aureus treatment evaluation: study protocol for a randomised controlled trial

Abstract Background Exotoxins are important virulence factors in Staphylococcus aureus. Clindamycin, a protein synthesis inhibitor antibiotic, is thought to limit exotoxin production and improve outcomes in severe S. aureus infections. However, randomised prospective data to support this are lacking...

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Main Authors: Ravindra Dotel, Steven Y. C. Tong, Asha Bowen, Jane N. Nelson, Matthew V. N. O’Sullivan, Anita J. Campbell, Brendan J. McMullan, Philip N. Britton, Joshua R. Francis, Damon P. Eisen, Owen Robinson, Laurens Manning, Joshua S. Davis
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-06-01
Colecção:Trials
Assuntos:
Staphylococcus aureus
Exotoxins
Prospective studies
Clindamycin
Leukocidins
Acesso em linha:http://link.springer.com/article/10.1186/s13063-019-3452-y
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