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Identification of Antimotilins, Novel Inhibitors of Helicobacter pylori Flagellar Motility That Inhibit Stomach Colonization in a Mouse Model

ABSTRACT New treatment options against the widespread cancerogenic gastric pathogen Helicobacter pylori are urgently needed. We describe a novel screening procedure for inhibitors of H. pylori flagellar biosynthesis. The assay is based on a flaA flagellin gene-luciferase reporter fusion in H. pylori...

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Main Authors: Sebastian Suerbaum, Nina Coombs, Lubna Patel, Dimitri Pscheniza, Katharina Rox, Christine Falk, Achim D. Gruber, Olivia Kershaw, Patrick Chhatwal, Mark Brönstrup, Ursula Bilitewski, Christine Josenhans
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2022-04-01
Serier:mBio
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Online adgang:https://journals.asm.org/doi/10.1128/mbio.03755-21
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