Leishmania LABCG1 and LABCG2 transporters are involved in virulence and oxidative stress: functional linkage with autophagy

Abstract Background The G subfamily of ABC (ATP-binding cassette) transporters of Leishmania include 6 genes (ABCG1-G6), some with relevant biological functions associated with drug resistance and phospholipid transport. Several studies have shown that Leishmania LABCG2 transporter plays a role in t...

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Detalhes bibliográficos
Main Authors: José Ignacio Manzano, Ana Perea, David León-Guerrero, Jenny Campos-Salinas, Lucia Piacenza, Santiago Castanys, Francisco Gamarro
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2017-05-01
Colecção:Parasites & Vectors
Assuntos:
Leishmania
ABC transporters
Virulence
Metacyclogenesis
Autophagy
Oxidative stress
Acesso em linha:http://link.springer.com/article/10.1186/s13071-017-2198-1
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