Junctional E-cadherin/p120-catenin Is Correlated with the Absence of Supporting Cells to Hair Cells Conversion in Postnatal Mice Cochleae

Notch inhibition is known to generate supernumerary hair cells (HCs) at the expense of supporting cells (SCs) in the mammalian inner ear. However, inhibition of Notch activity becomes progressively less effective at inducing SC-to-HC conversion in the postnatal cochlea and balance organs as the anim...

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Bibliographic Details
Main Authors: Wen-wei Luo, Xin-wei Wang, Rui Ma, Fang-lu Chi, Ping Chen, Ning Cong, Yu-yan Gu, Dong-dong Ren, Juan-mei Yang
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Molecular Neuroscience
Subjects:
cochlea
supporting cells
hair cells
SC-to-HC conversion
DAPT
E-cadherin/p120ctn complexes
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00020/full
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