Glial cells maintain synapses by inhibiting an activity-dependent retrograde protease signal.

Glial cells regulate multiple aspects of synaptogenesis. In the absence of Schwann cells, a peripheral glial cell, motor neurons initially innervate muscle but then degenerate. Here, using a genetic approach, we show that neural activity-regulated negative factors produced by muscle drive neurodegen...

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Bibliographic Details
Main Authors: Thomas W Gould, Bertha Dominguez, Fred de Winter, Gene W Yeo, Patrick Liu, Balaji Sundararaman, Thomas Stark, Anthony Vu, Jay L Degen, Weichun Lin, Kuo-Fen Lee
Format: Artigo
Language:Inglês
Published: Public Library of Science (PLoS) 2019-03-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC6417855?pdf=render
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