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NF-κB c-Rel Dictates the Inflammatory Threshold by Acting as a Transcriptional Repressor

Summary: NF-κB/Rel family of transcription factors plays a central role in initiation and resolution of inflammatory responses. Here, we identified a function of the NF-κB subunit c-Rel as a transcriptional repressor of inflammatory genes. Genetic deletion of c-Rel substantially potentiates the expr...

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Detalhes bibliográficos
Main Authors: Tristan James de Jesús, Parameswaran Ramakrishnan
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020-03-01
Colecção:iScience
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2589004220300602
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