Tumor suppressor function of Syk in human MCF10A in vitro and normal mouse mammary epithelium in vivo.

The normal function of Syk in epithelium of the developing or adult breast is not known, however, Syk suppresses tumor growth, invasion, and metastasis in breast cancer cells. Here, we demonstrate that in the mouse mammary gland, loss of one Syk allele profoundly increases proliferation and ductal b...

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Main Authors: You Me Sung, Xuehua Xu, Junfeng Sun, Duane Mueller, Kinza Sentissi, Peter Johnson, Elana Urbach, Françoise Seillier-Moiseiwitsch, Michael D Johnson, Susette C Mueller
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science (PLoS) 2009-10-01
Series:PLoS ONE
Acceso en liña:http://europepmc.org/articles/PMC2759536?pdf=render
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