A direct sequencing assay for pharmacogenetic testing of thiopurine-intolerant NUDT15 alleles in an Asian population

Abstract Objective The nucleoside diphosphate linked moiety X (Nudix)-Type motif 15 (NUDT15) enzyme is involved in thiopurine metabolism. Genetic variants in the NUDT15 gene result in decreased NUDT15 activity, which in addition to decreased thiopurine S-methyltransferase (TPMT) activity, contribute...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Kok-Siong Poon, Izz Irfan B. Imran, Silvester Kheng-Han Chew, Patrice Tan, Karen Mei-Ling Tan
Formato: Artigo
Lenguaje:Inglês
Publicado: BMC 2022-04-01
Colección:BMC Research Notes
Materias:
NUDT15
Thiopurine
Pharmacogenetics
Direct sequencing
Acceso en línea:https://doi.org/10.1186/s13104-021-05821-3
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares