Two-year intermittent exposure of a multiwalled carbon nanotube by intratracheal instillation induces lung tumors and pleural mesotheliomas in F344 rats

Abstract Background A mounting number of studies have been documenting the carcinogenic potential of multiwalled carbon nanotubes (MWCNTs); however, only a few studies have evaluated the pulmonary carcinogenicity of MWCNTs in vivo. A 2-year inhalation study demonstrated that MWNT-7, a widely used MW...

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Main Authors: Motoki Hojo, Ai Maeno, Yoshimitsu Sakamoto, Aya Ohnuki, Yukie Tada, Yukio Yamamoto, Kiyomi Ikushima, Ryota Inaba, Jin Suzuki, Yuhji Taquahashi, Satoshi Yokota, Norihiro Kobayashi, Makoto Ohnishi, Yuko Goto, Takamasa Numano, Hiroyuki Tsuda, David B. Alexander, Jun Kanno, Akihiko Hirose, Akiko Inomata, Dai Nakae
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-05-01
Colecção:Particle and Fibre Toxicology
Assuntos:
MWCNT
Carcinogenicity
Intratracheal instillation
Lung tumors
Pleural mesothelioma
Lung burden
Acesso em linha:https://doi.org/10.1186/s12989-022-00478-7
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