Aberrant methylation of Pax3 gene and neural tube defects in association with exposure to polycyclic aromatic hydrocarbons

Abstract Background Neural tube defects (NTDs) are common and severe congenital malformations. Pax3 is an essential gene for neural tube closure in mice but it is unknown whether altered expression or methylation of PAX3 contributes to human NTDs. We examined the potential role of hypermethylation o...

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Hlavní autoři: Shanshan Lin, Aiguo Ren, Linlin Wang, Chloe Santos, Yun Huang, Lei Jin, Zhiwen Li, Nicholas D. E. Greene
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2019-01-01
Edice:Clinical Epigenetics
Témata:
Neural tube defects
Pax3 gene
Methylation
Benzo[a]pyrene
Polycyclic aromatic hydrocarbon
On-line přístup:http://link.springer.com/article/10.1186/s13148-019-0611-7
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