The Role of Heterotypic DENV-specific CD8+T Lymphocytes in an Immunocompetent Mouse Model of Secondary Dengue Virus Infection

Dengue is the most prevalent arthropod-borne viral disease worldwide and is caused by the four dengue virus serotypes (DENV-1-4). Sequential heterologous DENV infections can be associated with severe disease manifestations. Here, we present an immunocompetent mouse model of secondary DENV infection...

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Bibliographic Details
Main Authors: Laura B. Talarico, Juan P. Batalle, Alana B. Byrne, Jorge M. Brahamian, Adrián Ferretti, Ayelén G. García, Aldana Mauri, Carla Simonetto, Diego R. Hijano, Andrea Lawrence, Patricio L. Acosta, Mauricio T. Caballero, Yésica Paredes Rojas, Lorena I. Ibañez, Guillermina A. Melendi, Félix A. Rey, Elsa B. Damonte, Eva Harris, Fernando P. Polack
Format: Artigo
Language:Inglês
Published: Elsevier 2017-06-01
Series:EBioMedicine
Subjects:
Dengue virus
Immunocompetent mouse model
Secondary infection
Immune response
CD8+ T lymphocytes
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417301883
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