Pharmacodynamic Evaluation of Zoliflodacin Treatment of Neisseria gonorrhoeae Strains With Amino Acid Substitutions in the Zoliflodacin Target GyrB Using a Dynamic Hollow Fiber Infection Model

Novel antimicrobials for effective treatment of uncomplicated gonorrhea are essential, and the first-in-class, oral spiropyrimidinetrione DNA gyrase B inhibitor zoliflodacin appears promising. Using our newly developed Hollow Fiber Infection Model (HFIM), the pharmacodynamics of zoliflodacin was exa...

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Main Authors: Susanne Jacobsson, Daniel Golparian, Joakim Oxelbark, Francois Franceschi, David Brown, Arnold Louie, George Drusano, Magnus Unemo
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Pharmacology
Assuntos:
Neisseria gonorrhoeae
hollow fiber infection model
zoliflodacin
antimicrobial treatment
pharmacodynamics
pharmacokinetics
Acceso en liña:https://www.frontiersin.org/articles/10.3389/fphar.2022.874176/full
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