Inhibition of proprotein convertase subtilisin/kexin type 9 attenuates 2,4,6‐trinitrobenzenesulfonic acid‐induced colitis via repressing toll‐like receptor 4/nuclear factor‐kappa B

Abstract Inflammatory bowel disease (IBD) is characterized by recurring inflammatory disorders in digestive system, and devoid of effective treatment. Proprotein convertase subtilisin/kexin type 9 (PCSK9), stimulated via inflammation whose inhibition could decrease secretion of inflammatory factors....

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Hauptverfasser: Lei Lei, Xu Li, You‐Jun Yuan, Zhi‐Li Chen, Jian‐Hua He, Jian‐Hua Wu, Xiao‐Sheng Cai
Format: Artigo
Sprache:Inglês
Veröffentlicht: Wiley 2020-09-01
Schriftenreihe:Kaohsiung Journal of Medical Sciences
Schlagworte:
colitis
inflammation
NF‐κB
PCSK9
TLR4
Online Zugang:https://doi.org/10.1002/kjm2.12225
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