Molecular Dynamics Simulations of the STAS Domains of Rat Prestin and Human Pendrin Reveal Conformational Motions in Conserved Flexible Regions

Background: Molecular dynamics (MD) simulations provide valuable information on the conformational changes that accompany time-dependent motions in proteins. The reported crystal structure of rat prestin (PDB 3LLO) is remarkable for an α1-α2 inter-helical angle that differs substantially from those...

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Main Authors: Alok K. Sharma, Israel Zelikovic, Seth L. Alper
Formato: Artigo
Idioma:Inglês
Publicado: Cell Physiol Biochem Press GmbH & Co KG 2014-02-01
Series:Cellular Physiology and Biochemistry
Assuntos:
Molecular dynamics simulation
Atomic motions
RMSD
RMSF
Conformational change
Rat prestin
Human pendrin
STAS domain
Acceso en liña:http://www.karger.com/Article/FullText/358638
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