Frequency of circulating CD8+CD73+T cells is associated with survival in nivolumab-treated melanoma patients

Abstract Background PD-1 blocking agents, such as nivolumab, have demonstrated clear anti-tumor effects and clinical benefits in a subset of patients with advanced malignancies. Nonetheless, more efforts are needed to identify reliable biomarkers for outcome, to correctly select patients who will be...

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Detalhes bibliográficos
Main Authors: Mariaelena Capone, Federica Fratangelo, Diana Giannarelli, Claudia Sorrentino, Roberta Turiello, Serena Zanotta, Domenico Galati, Gabriele Madonna, Marilena Tuffanelli, Luigi Scarpato, Antonio M. Grimaldi, Assunta Esposito, Rosa Azzaro, Antonio Pinto, Ernesta Cavalcanti, Aldo Pinto, Silvana Morello, Paolo A. Ascierto
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2020-03-01
Colecção:Journal of Translational Medicine
Assuntos:
Immunotherapy
Nivolumab
Metastatic melanoma
CD73
Circulating CD8+ lymphocytes
Acesso em linha:http://link.springer.com/article/10.1186/s12967-020-02285-0
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