Abrupt and altered cell-type specific DNA methylation profiles in blood during acute HIV infection persists despite prompt initiation of ART.

HIV-1 disrupts the host epigenetic landscape with consequences for disease pathogenesis, viral persistence, and HIV-associated comorbidities. Here, we examined how soon after infection HIV-associated epigenetic changes may occur in blood and whether early initiation of antiretroviral therapy (ART) i...

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Main Authors: Michael J Corley, Carlo Sacdalan, Alina P S Pang, Nitiya Chomchey, Nisakorn Ratnaratorn, Victor Valcour, Eugene Kroon, Kyu S Cho, Andrew C Belden, Donn Colby, Merlin Robb, Denise Hsu, Serena Spudich, Robert Paul, Sandhya Vasan, Lishomwa C Ndhlovu, SEARCH010/RV254 and SEARCH013/RV304 study groups
Format: Artigo
Language:Inglês
Published: Public Library of Science (PLoS) 2021-08-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009785
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