miR-23b and miR-27b are oncogenic microRNAs in breast cancer: evidence from a CRISPR/Cas9 deletion study

Abstract Background Altered expression of microRNAs (miRNAs) is known to contribute to cancer progression. miR-23b and miR-27b, encoded within the same miRNA cluster, are reported to have both tumor suppressive and oncogenic activity across human cancers, including breast cancer. Methods To clarify...

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Autores principales: Bethany N. Hannafon, Angela Cai, Cameron L. Calloway, Yi-Fan Xu, Roy Zhang, Kar-Ming Fung, Wei-Qun Ding
Formato: Artigo
Lenguaje:Inglês
Publicado: BMC 2019-06-01
Colección:BMC Cancer
Materias:
CRISPR/Cas9
microRNA
Breast cancer
Acceso en línea:http://link.springer.com/article/10.1186/s12885-019-5839-2
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