Arsenic exposure and calpain-10 polymorphisms impair the function of pancreatic beta-cells in humans: a pilot study of risk factors for T2DM.

The incidence of type 2 diabetes mellitus (T2DM) is increasing worldwide and diverse environmental and genetic risk factors are well recognized. Single nucleotide polymorphisms (SNPs) in the calpain-10 gene (CAPN-10), which encodes a protein involved in the secretion and action of insulin, and chron...

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Autores principales: Andrea Díaz-Villaseñor, Laura Cruz, Arturo Cebrián, Raúl U Hernández-Ramírez, Marcia Hiriart, Gonzálo García-Vargas, Susana Bassol, Monserrat Sordo, A Jay Gandolfi, Walter T Klimecki, Lizbeth López-Carillo, Mariano E Cebrián, Patricia Ostrosky-Wegman
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science (PLoS) 2013-01-01
Colección:PLoS ONE
Acceso en línea:http://europepmc.org/articles/PMC3551951?pdf=render
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