Histones, DNA, and Citrullination Promote Neutrophil Extracellular Trap Inflammation by Regulating the Localization and Activation of TLR4

Summary: Neutrophil extracellular traps (NETs) promote atherosclerosis by inducing proinflammatory cytokines, but the underlying mechanism remains unknown. NET DNA is immunogenic, but given the cytotoxicity of NET histones, it is unclear how it activates cells without killing them. Here, we show tha...

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Bibliographic Details
Main Authors: Theodora-Dorita Tsourouktsoglou, Annika Warnatsch, Marianna Ioannou, Dennis Hoving, Qian Wang, Venizelos Papayannopoulos
Format: Artigo
Language:Inglês
Published: Elsevier 2020-05-01
Series:Cell Reports
Subjects:
inflammation
histones
chromatin
DNA
TLR4
IL-1
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720305519
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