Human Cortical Pyramidal Neurons: From Spines to Spikes via Models

We present detailed models of pyramidal cells from human neocortex, including models on their excitatory synapses, dendritic spines, dendritic NMDA- and somatic/axonal Na+ spikes that provided new insights into signal processing and computational capabilities of these principal cells. Six human laye...

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Detalhes bibliográficos
Main Authors: Guy Eyal, Matthijs B. Verhoog, Guilherme Testa-Silva, Yair Deitcher, Ruth Benavides-Piccione, Javier DeFelipe, Christiaan P. J. de Kock, Huibert D. Mansvelder, Idan Segev
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018-06-01
Colecção:Frontiers in Cellular Neuroscience
Assuntos:
human pyramidal cells
compartmental modeling
non-linear dendrites
cortical excitatory synapses
neuron computation
multi objective optimization
Acesso em linha:https://www.frontiersin.org/article/10.3389/fncel.2018.00181/full
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