Human antibodies against the myelin oligodendrocyte glycoprotein can cause complement-dependent demyelination

Abstract Background Antibodies to the myelin oligodendrocyte glycoprotein (MOG) are associated with a subset of inflammatory demyelinating diseases of the central nervous system such as acute disseminated encephalomyelitis and neuromyelitis optica spectrum disorders. However, whether human MOG antib...

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Detalhes bibliográficos
Main Authors: Patrick Peschl, Kathrin Schanda, Bleranda Zeka, Katherine Given, Denise Böhm, Klemens Ruprecht, Albert Saiz, Andreas Lutterotti, Kevin Rostásy, Romana Höftberger, Thomas Berger, Wendy Macklin, Hans Lassmann, Monika Bradl, Jeffrey L. Bennett, Markus Reindl
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2017-10-01
Colecção:Journal of Neuroinflammation
Assuntos:
Myelin oligodendrocyte glycoprotein
MOG
Antibodies
Organotypic slice culture
EAE
Neuromyelitis optica spectrum disorders
Acesso em linha:http://link.springer.com/article/10.1186/s12974-017-0984-5
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