Lanreotide Induces Cytokine Modulation in Intestinal Neuroendocrine Tumors and Overcomes Resistance to Everolimus

Somatostatin analogs mantain their major role in the treatment of patients with advanced neuroendocrine tumors (NETs) and have multiple modulatory effects on the immune system. Here, we evaluated the effects of lanreotide treatment on expression of Th1, Th2 cytokine patterns in serum of patients wit...

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Detalhes bibliográficos
Main Authors: Concetta Sciammarella, Amalia Luce, Ferdinando Riccardi, Carmela Mocerino, Roberta Modica, Massimiliano Berretta, Gabriella Misso, Alessia Maria Cossu, Annamaria Colao, Giovanni Vitale, Alois Necas, Jan Fedacko, Marilena Galdiero, Pierpaolo Correale, Antongiulio Faggiano, Michele Caraglia, Anna Capasso, Anna Grimaldi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-07-01
Colecção:Frontiers in Oncology
Assuntos:
neuroendocrine tumors
cytokines
somatostatin analogs
mTOR–mammalian target of rapamycin
drug-resistance
Acesso em linha:https://www.frontiersin.org/article/10.3389/fonc.2020.01047/full
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