A Proof-of-Mechanism Study to Test Effects of the NMDA Receptor Antagonist Lanicemine on Behavioral Sensitization in Individuals With Symptoms of PTSD

Background: Individuals with post-traumatic stress disorder (PTSD) have a heightened sensitivity to subsequent stressors, addictive drugs, and symptom recurrence, a form of behavioral sensitization. N-methyl-D-aspartate receptors (NMDARs) are involved in the establishment and activation of sensitize...

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Main Authors: Marijn Lijffijt, Charles E. Green, Nicholas Balderston, Tabish Iqbal, Megan Atkinson, Brittany Vo-Le, Bylinda Vo-Le, Brittany O’Brien, Christian Grillon, Alan C. Swann, Sanjay J. Mathew
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019-12-01
Colecção:Frontiers in Psychiatry
Assuntos:
behavioral sensitization
NMDA receptor
hyperarousal
neurophysiology
post-traumatic stress disorder
anxiety potentiated startle
Acesso em linha:https://www.frontiersin.org/article/10.3389/fpsyt.2019.00846/full
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