Effect of Formulation Factors and Oxygen Levels on the Stability of Aqueous Injectable Solution Containing Pemetrexed

The aim of this study was to investigate the effects of various parameters at each control strategy in drug product degradation on the stability of pemetrexed in injectable aqueous solution. A forced degradation study confirmed that oxidation is the main mechanism responsible for the degradation of...

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Autores principales: Dong Han Won, Heejun Park, Eun-Sol Ha, Yong Min Kim, Hyung Don Hwang, Sun Woo Jang, Min-Soo Kim
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI AG 2020-01-01
Colección:Pharmaceutics
Materias:
pemetrexed
stability
aqueous injectable solution
oxidation
control strategy
Acceso en línea:https://www.mdpi.com/1999-4923/12/1/46
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