Dual specificity phosphatase 6 deficiency is associated with impaired systemic glucose tolerance and reversible weight retardation in mice.

Here, we aimed to investigate the potential role of DUSP6, a dual specificity phosphatase, that specifically inactivates extracellular signal-regulated kinase (ERK), for the regulation of body weight and glucose homeostasis. We further assessed whether metabolic challenges affect Dusp6 expression in...

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Main Authors: Katrin Pfuhlmann, Paul T Pfluger, Sonja C Schriever, Timo D Müller, Matthias H Tschöp, Kerstin Stemmer
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science (PLoS) 2017-01-01
Serija:PLoS ONE
Online dostop:http://europepmc.org/articles/PMC5584967?pdf=render
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