5-fluorouracil treatment of patient-derived scaffolds from colorectal cancer reveal clinically critical information

Abstract Background Colorectal cancer is a commonly diagnosed cancer worldwide. Unfortunately, many patients do not respond to standard chemotherapy treatments and develop disease relapse and metastases. Besides cancer cell specific genetic changes, heterogeneity in the tumor microenvironment contri...

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Главные авторы: Simona Salerno, Anders Ståhlberg, André Holdfeldt, Elinor Bexe Lindskog, Göran Landberg
Формат: Artigo
Язык:Inglês
Опубликовано: BMC 2022-05-01
Серии:Journal of Translational Medicine
Предметы:
Colorectal cancer
Patient-derived scaffold
Decellularized matrix
5-fluorouracil
Drug screening
Online-ссылка:https://doi.org/10.1186/s12967-022-03423-6
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