Micro-environmental mechanical stress controls tumor spheroid size and morphology by suppressing proliferation and inducing apoptosis in cancer cells.

Compressive mechanical stress produced during growth in a confining matrix limits the size of tumor spheroids, but little is known about the dynamics of stress accumulation, how the stress affects cancer cell phenotype, or the molecular pathways involved.We co-embedded single cancer cells with fluor...

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Hlavní autoři: Gang Cheng, Janet Tse, Rakesh K Jain, Lance L Munn
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science (PLoS) 2009-01-01
Edice:PLoS ONE
On-line přístup:http://europepmc.org/articles/PMC2645686?pdf=render
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