Hypogalactosylation of immunoglobulin G in rheumatoid arthritis: relationship to HLA-DRB1 shared epitope, anticitrullinated protein antibodies, rheumatoid factor, and correlation with inflammatory activity

Abstract Background Galactosylation of immunoglobulin G (IgG) is reduced in rheumatoid arthritis (RA) and assumed to correlate with inflammation and altered humoral immunity. IgG hypogalactosylation also increases with age. To investigate dependencies in more detail, we compared IgG hypogalactosylat...

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Detalhes bibliográficos
Main Authors: Christian Schwedler, Thomas Häupl, Ulrich Kalus, Véronique Blanchard, Gerd-Rüdiger Burmester, Denis Poddubnyy, Berthold Hoppe
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2018-03-01
Colecção:Arthritis Research & Therapy
Assuntos:
Rheumatoid arthritis (RA)
Axial spondyloarthritis (axSpA)
HLA-DRB1 shared epitope (HLA-DRB1 SE)
Anticitrullinated protein antibodies (ACPA)
Rheumatoid factor (RF)
IgG hypogalactosylation
Acesso em linha:http://link.springer.com/article/10.1186/s13075-018-1540-0
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