Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion.

WNK1--a serine/threonine kinase involved in electrolyte homeostasis and blood pressure (BP) control--is an excellent candidate gene for essential hypertension (EH). We and others have previously reported association between WNK1 and BP variation. Using tag SNPs (tSNPs) that capture 100% of common WN...

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Autori principali: Stephen Newhouse, Martin Farrall, Chris Wallace, Mimoza Hoti, Beverley Burke, Philip Howard, Abiodun Onipinla, Kate Lee, Sue Shaw-Hawkins, Richard Dobson, Morris Brown, Nilesh J Samani, Anna F Dominiczak, John M Connell, G Mark Lathrop, Jaspal Kooner, John Chambers, Paul Elliott, Robert Clarke, Rory Collins, Maris Laan, Elin Org, Peeter Juhanson, Gudrun Veldre, Margus Viigimaa, Susana Eyheramendy, Francesco P Cappuccio, Chen Ji, Roberto Iacone, Pasquale Strazzullo, Meena Kumari, Michael Marmot, Eric Brunner, Mark Caulfield, Patricia B Munroe
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2009-01-01
Serie:PLoS ONE
Accesso online:http://europepmc.org/articles/PMC2661139?pdf=render
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