Bioactive glass selectively promotes cytotoxicity towards giant cell tumor of bone derived neoplastic stromal cells and induces MAPK signalling dependent autophagy

Giant cell tumors of bone (GCTB) are associated with massive bone destructions and high recurrence rates. In a previous study, we observed cytotoxic effects of three different compositions of bioactive glasses (BGs) towards GCTSC but not bone marrow derived stromal cells (BMSC) indicating that BGs r...

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Main Authors: Joerg Fellenberg, Sarina Losch, Burkhard Lehner, Marcela Arango-Ospina, Aldo R. Boccaccini, Fabian Westhauser
Formáid: Artigo
Teanga:Inglês
Foilsithe: KeAi Communications Co., Ltd. 2022-09-01
Sraith:Bioactive Materials
Ábhair:
Bioactive glass
Giant cell tumor of bone
Mesenchymal stromal cells
Mitogen-activated protein kinases
Cytotoxicity
Autophagy
Rochtain Ar Líne:http://www.sciencedirect.com/science/article/pii/S2452199X22000950
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