Bioactive glass selectively promotes cytotoxicity towards giant cell tumor of bone derived neoplastic stromal cells and induces MAPK signalling dependent autophagy

Giant cell tumors of bone (GCTB) are associated with massive bone destructions and high recurrence rates. In a previous study, we observed cytotoxic effects of three different compositions of bioactive glasses (BGs) towards GCTSC but not bone marrow derived stromal cells (BMSC) indicating that BGs r...

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Detalhes bibliográficos
Main Authors: Joerg Fellenberg, Sarina Losch, Burkhard Lehner, Marcela Arango-Ospina, Aldo R. Boccaccini, Fabian Westhauser
Formato: Artigo
Idioma:Inglês
Publicado em: KeAi Communications Co., Ltd. 2022-09-01
Colecção:Bioactive Materials
Assuntos:
Bioactive glass
Giant cell tumor of bone
Mesenchymal stromal cells
Mitogen-activated protein kinases
Cytotoxicity
Autophagy
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2452199X22000950
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