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Contribution of rare whole-genome sequencing variants to plasma protein levels and the missing heritability

Despite the success of genome-wide association studies, much of the genetic contribution to complex traits remains unexplained. Here, the authors identify effects by rare variants on plasma proteins, and estimate the contribution of rare variants to the heritability.

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Detalhes bibliográficos
Main Authors: Marcin Kierczak, Nima Rafati, Julia Höglund, Hadrien Gourlé, Valeria Lo Faro, Daniel Schmitz, Weronica E. Ek, Ulf Gyllensten, Stefan Enroth, Diana Ekman, Björn Nystedt, Torgny Karlsson, Åsa Johansson
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2022-05-01
Colecção:Nature Communications
Acesso em linha:https://doi.org/10.1038/s41467-022-30208-8
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