Nanobody-based CAR-T cells for cancer immunotherapy

Abstract Chimeric antigen receptor T-cell (CAR-T) therapy is the result of combining genetic engineering-based cancer immunotherapy with adoptive cell therapy (ACT). CAR-T therapy has been successful in treating various types of hematological cancers. CARs are receptors made of an extracellular doma...

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Detalhes bibliográficos
Main Authors: Pouya Safarzadeh Kozani, Abdolhossein Naseri, Seyed Mohamad Javad Mirarefin, Faeze Salem, Mojtaba Nikbakht, Sahar Evazi Bakhshi, Pooria Safarzadeh Kozani
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-04-01
Colecção:Biomarker Research
Assuntos:
Chimeric antigen receptor
Single-chain fragment variable
Nanobody
VHH
Solid tumors
Hematologic malignancy
Acesso em linha:https://doi.org/10.1186/s40364-022-00371-7
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