How Does the CO<sub>2</sub> in Supercritical State Affect the Properties of Drug-Polymer Systems, Dissolution Performance and Characteristics of Tablets Containing Bicalutamide?

The increasing demand for novel drug formulations has caused the introduction of the supercritical fluid technology, CO<sub>2</sub> in particular, into pharmaceutical technology as a method enabling the reduction of particle size and the formation of inclusion complexes and solid dispers...

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Main Authors: Agata Antosik-Rogóż, Joanna Szafraniec‑Szczęsny, Krzysztof Chmiel, Justyna Knapik-Kowalczuk, Mateusz Kurek, Karolina Gawlak, Vittorio P. Danesi, Marian Paluch, Renata Jachowicz
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-06-01
Colecção:Materials
Assuntos:
Bicalutamide
Poloxamer<sup>®</sup> 407
Macrogol 6000
supercritical carbon dioxide
solid dispersions
dissolution rate
Acesso em linha:https://www.mdpi.com/1996-1944/13/12/2848
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