Host MKRN1-Mediated Mycobacterial PPE Protein Ubiquitination Suppresses Innate Immune Response

Mycobacterium tuberculosis (Mtb), as an important intracellular pathogen, can invade and survive in macrophages and is capable of escaping the clearance of immune system. Despite decades of research efforts, the precise mechanism of immune escape and the virulence factors encoded by Mtb involved rem...

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Main Authors: Yafeng Dou, Yan Xie, Lingyun Zhang, Sheng Liu, Dandan Xu, Yuying Wei, Yongshuai Li, Xiao-Lian Zhang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-05-01
Colecção:Frontiers in Immunology
Assuntos:
Mycobacterium tuberculosis
PPE68
MKRN1
ubiquitination
innate immune response
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2022.880315/full
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