Heterozygous Genetic Variants in Autosomal Recessive Genes of the Leptin-Melanocortin Signalling Pathway Are Associated With the Development of Childhood Obesity

Monogenic obesity is a severe, genetically determined disorder that affects up to 1/1000 newborns. Recent reports on potential new therapeutics and innovative clinical approaches have highlighted the need for early identification of individuals with rare genetic variants that can alter the functioni...

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Main Authors: Robert Šket, Primož Kotnik, Barbara Jenko Bizjan, Valentina Kocen, Matej Mlinarič, Tine Tesovnik, Maruša Debeljak, Tadej Battelino, Jernej Kovač
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-04-01
Serier:Frontiers in Endocrinology
Fag:
childhood obesity
leptin-melanocortin pathway
hyperphagia
next-generation sequencing
genetic screening
Online adgang:https://www.frontiersin.org/articles/10.3389/fendo.2022.832911/full
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