Mechanism of GAPDH Redox Signaling by H<sub>2</sub>O<sub>2</sub> Activation of a Two−Cysteine Switch

Oxidation of glyceraldehyde−3−phosphate dehydrogenase (GAPDH) by reactive oxygen species such as H<sub>2</sub>O<sub>2</sub> activate pleiotropic signaling pathways is associated with pathophysiological cell fate decisions. Oxidized GAPDH binds chaperone proteins with transloc...

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Detalhes bibliográficos
Main Authors: Paul A. Hyslop, Michael O. Chaney
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-04-01
Colecção:International Journal of Molecular Sciences
Assuntos:
oxidative stress
redox signaling
glyceraldehyde−3−phosphate dehydrogenase
hydrogen peroxide
two−cysteine redox switch
thiosulfinic ester
Acesso em linha:https://www.mdpi.com/1422-0067/23/9/4604
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