Identification of new pyrazolyl piperidine molecules as factor Xa inhibitors: Design, synthesis, in silico, and biological evaluation

Coagulation factor Xa (FXa), a serine endopeptidase is a common coagulation factor activated as a result of the initiation of both intrinsic and extrinsic blood coagulation pathways. Hence, FXa has been regarded as an important pharmaceutical target for the treatment of thrombotic disorders. In this...

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Main Authors: Rahul H. Rayani, Jigar Y. Soni, Deepa R. Parmar, Rakesh V. Kusurkar, Ibrahim.H. Eissae, Ahmed M. Metwaly, Ahmed Khalil, Vishwanath Zunjar, Satyanarayana Battula, Sarfaraj Niazi
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2022-01-01
Colecção:Results in Chemistry
Assuntos:
ADMET
Anti-coagulation
DFT study
Factor Xa
Molecular docking
Pyrazolyl piperidine
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2211715622000741
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