EZH2 inhibitors-mediated epigenetic reactivation of FOSB inhibits triple-negative breast cancer progress

Abstract Background Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer that lacks expression of estrogen receptor (ER) and progesterone receptor (PR) and the human epidermal growth factor receptor 2 (HER2) gene. Chemotherapy remains the standard of care for TNBC tre...

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Huvudupphovsmän: Ruishan Zhang, Xiang Li, Zhuangkai Liu, Yuying Wang, Hao Zhang, Hong Xu
Materialtyp: Artigo
Språk:Inglês
Publicerad: BMC 2020-05-01
Serie:Cancer Cell International
Ämnen:
TNBC
EZH2
FOSB
C/EBPβ
Epigenetic inactivation
Länkar:http://link.springer.com/article/10.1186/s12935-020-01260-5
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