Inhibition of p53 and/or AKT as a new therapeutic approach specifically targeting ALT cancers

Abstract While the majority of all human cancers counteract telomere shortening by expressing telomerase, ~15% of all cancers maintain telomere length by a telomerase-independent mechanism known as alternative lengthening of telomeres (ALT). Here, we show that high load of intrinsic DNA damage is pr...

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Detalhes bibliográficos
Main Authors: Yuanlong Ge, Shu Wu, Zepeng Zhang, Xiaocui Li, Feng Li, Siyu Yan, Haiying Liu, Junjiu Huang, Yong Zhao
Formato: Artigo
Idioma:Inglês
Publicado em: SpringerOpen 2019-05-01
Colecção:Protein & Cell
Assuntos:
ALT
p53
AKT
DNA damage
apoptosis
telomeres
Acesso em linha:http://link.springer.com/article/10.1007/s13238-019-0634-z
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