External Evaluation of Population Pharmacokinetic Models to Inform Precision Dosing of Meropenem in Critically Ill Patients

Routine clinical meropenem therapeutic drug monitoring data can be applied to model-informed precision dosing. The current study aimed to evaluate the adequacy and predictive capabilities of the published models with routine meropenem data and identify the dosing adaptations using a priori and Bayes...

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Detalhes bibliográficos
Main Authors: Nan Yang, Jing Wang, Yueliang Xie, Junjie Ding, Cuifang Wu, Jingjing Liu, Qi Pei
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-05-01
Colecção:Frontiers in Pharmacology
Assuntos:
meropenem
population pharmacokinetics
external evaluation
critically ill patients
Bayesian forecasting
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2022.838205/full
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