BDNF-TrkB Signaling Coupled to nPKCε and cPKCβI Modulate the Phosphorylation of the Exocytotic Protein Munc18-1 During Synaptic Activity at the Neuromuscular Junction

Munc18-1, a neuron-specific member of the Sec1/Munc18 family, is involved in neurotransmitter release by binding tightly to syntaxin. Munc18-1 is phosphorylated by PKC on Ser-306 and Ser-313 in vitro which reduces the amount of Munc18-1 able to bind syntaxin. We have previously identified that PKC i...

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Bibliographic Details
Main Authors: Anna Simó, Laia Just-Borràs, Víctor Cilleros-Mañé, Erica Hurtado, Laura Nadal, Marta Tomàs, Neus Garcia, Maria A. Lanuza, Josep Tomàs
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
neuromuscular junction
muscle contraction
Munc18-1
BDNF-TrkB pathway
neurotrophic factors
PKC isoforms
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00207/full
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