Mitochondria transfer enhances proliferation, migration, and osteogenic differentiation of bone marrow mesenchymal stem cell and promotes bone defect healing

Abstract Background Bone marrow-derived mesenchymal stem cell (BMSC) transplantation is considered a promising therapeutic approach for bone defect repair. However, during the transplantation procedure, the functions and viability of BMSCs may be impaired due to extended durations of in vitro cultur...

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Main Authors: Yusi Guo, Xiaopei Chi, Yifan Wang, Boon Chin Heng, Yan Wei, Xuehui Zhang, Han Zhao, Ying Yin, Xuliang Deng
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2020-06-01
Series:Stem Cell Research & Therapy
Assuntos:
Mitochondria
Mitochondria transfer
BMSC function
Proliferation
Stem cell migration
Osteogenic differentiation
Acceso en liña:http://link.springer.com/article/10.1186/s13287-020-01704-9
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