Prophylactic NAC promoted hematopoietic reconstitution by improving endothelial cells after haploidentical HSCT: a phase 3, open-label randomized trial

Abstract Background Poor graft function (PGF) or prolonged isolated thrombocytopenia (PT), which are characterized by pancytopenia or thrombocytopenia, have become serious complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Our previous single-arm trial suggests that...

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Detalhes bibliográficos
Main Authors: Yu Wang, Yuan Kong, Hong-Yan Zhao, Yuan-Yuan Zhang, Ya-Zhe Wang, Lan-Ping Xu, Xiao-Hui Zhang, Kai-Yan Liu, Xiao-Jun Huang
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-04-01
Colecção:BMC Medicine
Assuntos:
N-Acetyl-L-cysteine
Poor hematopoietic reconstitution
Allogeneic hematopoietic stem cell transplantation
Endothelial cells
Bone marrow microenvironment
Acesso em linha:https://doi.org/10.1186/s12916-022-02338-9
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